Some of it is already made

A mimic for hsa-miR-155-5p is the same molecule this week as it was last week. So are the matched controls, the tracrRNA and the non-targeting guides. Those we keep on the shelf; there is nothing to synthesise when your order arrives, only something to pack.

They travel lyophilised at ambient temperature. That is the quiet advantage of this product class: no dry ice, no temperature logger, no customs officer wondering why a parcel needs refrigeration. Most destinations are 3 to 6 business days by courier.

Everything else is made to order, which is normally 2 to 5 business days from confirmation. Longer if you want PAGE purification, because that step trades yield for purity and we would rather repeat a synthesis than send you a thin tube.

Start from the experiment

Nobody wakes up wanting a 25 nmol desalted oligo. They want a qPCR assay that works. Pick the experiment and the scale, purification and modifications come pre-set. Change any of them.

qPCR and gene expression

Primer pairs, hydrolysis probes, reference gene assays.

Cloning and sequencing

Cloning primers, seamless assembly overhangs, universal vector primers.

Gene silencing

siRNA duplexes, miRNA mimics and inhibitors, matched controls.

Genome editing

sgRNA, crRNA with tracrRNA, ssODN donors, validation primers.

Genotyping and SNP

Allele-specific primers, genotyping probe pairs, blockers.

Imaging and hybridisation

FISH probes, molecular beacons, labelled oligos.

Conjugation and biosensing

Thiol, amino, biotin and click chemistry oligos.

Plates and large scale

96 and 384-well plates, normalised delivery, bulk synthesis.

With every order

Every price published

Complete price list on the site. You do not need to request a quotation to find out what something costs.

MS and COA with every lot

Mass spectrum and certificate of analysis issued for every synthesis lot and available in your account.

Sequences are never retained

Your sequences are used to fill your order and nothing else. You can delete them from your account at any time.

Remake or refund on failed QC

If a synthesis does not meet its stated QC specification we remake it or refund it. No evidence required from you.

Calculators

Five of them, free, no account. They run in your browser, so your sequences never reach us.

Melting temperature

Nearest-neighbour Tm under your salt and oligo concentration.

Reverse complement

Reverse, complement and translate in one step.

Bio calculator

OD, nmol, µg, resuspension and dilution, from a sequence-specific extinction coefficient.

Dimer and hairpin screen

Self-dimer, cross-dimer and hairpin complementarity.

Dye and quencher pairing

Checks a pair against published spectral ranges and suggests better matches.

There is no primer designer here on purpose. Designing one properly means checking specificity against a genome, and a tool that skips that step hands you a primer pair that looks fine and amplifies a pseudogene. We do that part by hand instead: send a gene symbol.

Where we are cheaper, and where we are not

Any supplier claiming to win every line has not looked at what large institutions actually pay.

+Consistently better

Probes, modified oligos and the fixed-sequence catalogue items. Framework discounts in this industry are deep on base synthesis and shallow on purification and modification. A dye, a quencher and an HPLC run are most of what a probe costs, and that is the part the discount barely touches.

Often not better

Plain primers, if you are at a large university with a framework agreement or a core facility down the corridor. Those prices are genuinely good and the tube arrives the same afternoon. Buy your primers there and your probes from us; we would rather say so than lose your trust on the first order.

See the full price list